Help


  • Purpose of the Interactive Results Tool: In order to make the results of our study more meaningful and accessible for reviewers and, eventually, readers, we developed a web-based tool to display the data. The tool is not meant to replace the need to upload raw data into public databases. Accordingly, the raw data will be uploaded into public databases prior to publication. Instead, the tool is designed to offer a rapid and interactive way to query the results. It was conceived as an alternative to the large, static documents with supplementary materials that are common at present in scientific publications.
  • What is displayed in the current version of the Interactive Results Tool: The entire set of results from the study is, in principle, accessible through the tool. However, there are many ways in which the data can be displayed and the final format and functionality of the tool will depend on feedback from editors and reviewers. The current version was designed to give reviewers and editors an idea of what can be accomplished. It contains three tables, each of them referenced in the manuscript. We have added interactivity to Table 1, as follows:

     

     

    • Clicking on a gene in the GeneID column displays a local Manhattan plot with the eQTL results for that gene. In the x-axis are SNPs within one-megabase intervals of the sequence for the expression reporter that was used to assay a particular transcript. In the y-axis are the negative log10 p-values of association for each SNP-transcript pair.

     

    • Clicking on an expression reporter in the ProbeID column displays box plots of the gene expression values measured from all individuals in the discovery cohort at each of the study's four time points (day 0 is the measurement obtained immediately prior to vaccination).

     

    • Clicking on a SNP in the rsID column displays box plots of gene expression by genotype at each of the study's four time points (day 0 is the measurement obtained immediately prior to vaccination).

 

 

Based on feedback from reviewers and editors, we can add similar or different interactivity to other tables and/or figures in the manuscript. We look forward to this feedback!